People who have been infected for the longest time: 78 nucleic acid tests, all positive

Fourteen months and 78 consecutive positive tests later, Kayasan is still alive and fighting COVID-19. Normally, mild cases of Novel Coronavirus infection begin to resolve and disappear within a few days, followed by negative test results. Why is there a situation like Kayasan?
Muzaffi Kayasan, a 56-year-old Turk, has not left his house in 14 months. He doesn’t know when he’ll be able to go out again.
In November 2020, Kayasan was diagnosed with COVID-19. After treatment in hospital, her symptoms improved and she returned home to self-quarantine. Since then, a total of 78 nucleic acid tests have been conducted at Kayasan as of February 20, 2022. Without exception, the results were all positive.
According to the Daily Mail, Kayasan is currently the world’s longest recorded person to have contracted the virus.
He hasn’t left his house in 500 days
Since self-isolation, Kayasan has lived alone in a small apartment. Despite his loneliness, he managed to maintain a positive mental state, even though he lost a lot of weight, which at its lowest point was less than 100 kg. Whenever family and friends came to visit him, he talked through the window of his apartment.
Kayasan, who has not left his home for nearly 500 days, does not know when he will recover. According to Turkey’s current quarantine policy, he cannot go out until the nucleic acid turns negative and is not eligible for vaccination until he fully recovers from COVID-19. The infection has left him unable to taste or smell. “My father felt trapped, like a red light in his life that he couldn’t pass.” “His son Gekhan Kayasan said.
Before Kayasan, Briton Dave Smith was thought to have had the virus the longest. Like Kayasan, he was “immune deficient” from leukemia and remained COVID-19 positive for 10 months. But with treatment with monoclonal antibodies, Smith eventually recovered from the new coronavirus.
If Kayasan stays positive, is there a chance he’ll get out? The issue may not be absolute now, as current local policy requires Kayasan to remain at home, but if you look at Europe as a whole, there are some countries that have completely lifted their quarantine restrictions.
Regardless, 14 months and 78 consecutive positive tests later, Kayasan is still alive and fighting COVID-19.
“Immune deficiency”
According to the reports so far available, normally mild cases of Novel Coronavirus infection begin to improve and disappear after a few days, followed by negative test results. Why is there a situation like Kayasan?
The main reason why Kayasan failed to turn positive from the new coronavirus was his “immune deficiency”. Prior to infection with novel Coronavirus, he was a patient with leukaemia.
“This extreme case of 78 nucleic acid positives over 14 months is scientifically understandable given the presence of leukaemia.” Fudan University affiliated Huashan hospital infection, deputy director of doctor Wang Xinyu said.
“Specifically, these respiratory infections, whether influenza or COVID-19, are acute infectious diseases. This means that although a person may develop symptoms within a short period of time, when the immune system is activated, it responds quickly and clears the virus within a short period of time. But for people with compromised immune systems, that’s not necessarily the case.” Wang xinyu said.
People with “immune deficiencies” are often more vulnerable to infectious diseases.
For leukemia patients like Kayasan, different chemotherapy or targeted drug treatments wipe out white blood cells, creating an “immune deficiency” state for a period of time that prevents the production of corresponding antibodies. Thus, novel Coronavirus is likely to survive in these patients. If the virus does not kill the host and continues to replicate, nucleic acid tests will be positive for a long time.
Wang xinyu reviewed the origin of the novel Coronavirus variant “Omicron”, which is currently prevalent worldwide. “The current theory is that the omicron variant was first detected in South Africa, probably because of the large number of HIV patients there. The novel coronavirus does not clear effectively in this part of the human body, survives for a long time, and is then more susceptible to mutation, leading to the evolution of the Omicron strain.”
Experts are closely monitoring kayasan’s cases for any risk of mutation.
Does Kayasan have to be quarantined for a long time
What will the future hold for Kayasan? In Wang xinyu’s view, nucleic acid positive means that there may still be a certain degree of infectivity. One possible “negative” approach for Kayasan would be to use a treatment similar to Dave Smith’s, potentially turning his Novel Coronavirus nucleic acid test negative.
Ms. Kayasan’s story is reminiscent of isolated cases in the country that have tested positive after quarantine. What’s the difference between this situation and kayasan repeatedly testing positive? Does the coronavirus have a concept of a “virus carrier”?
“Novel coronavirus infections can be divided into two types: confirmed cases and asymptomatic cases. When people say ‘carriers,’ they’re usually referring to some chronic infectious disease, and that’s not usually the definition for COVID-19.”
He said most of those who tested positive after a 21-day quarantine were asymptomatic. These asymptomatic infected people usually have a low level of virus in their bodies and have little possibility to infect others around them, making it difficult for them to become super spungers. Therefore, China’s prevention and control policies have not changed because of these small groups. The reasons for their repeated negative nucleic acid tests during isolation are complex and may have multiple factors.

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