3-Mercaptopropyltrimethoxysilane (MPTMS)

3-Mercaptopropyltrimethoxysilane (MPTMS) is an organosilicon compound with the formula [(CH3)2CHCH2]3Si(OCH3)3. It is a clear, colorless liquid with a mild odor. MPTMS is a versatile chemical with a variety of applications. It is used as a coupling agent in the manufacture of silicones, as a surface modifier in the treatment of metals and plastics, and as a reagent in organic synthesis.

MPTMS is a coupling agent that can be used to bond silicones to other materials. It does this by reacting with the hydroxyl groups on the surface of the other material. This creates a strong, durable bond between the silicone and the other material. MPTMS is used in a variety of applications, including the manufacture of silicone gaskets, seals, and adhesives.

MPTMS can also be used as a surface modifier. It can be used to modify the surface of metals and plastics to make them more resistant to corrosion and wear. MPTMS is also used to modify the surface of metals and plastics to make them more compatible with other materials. This is useful in applications such as the bonding of metals and plastics.

MPTMS is also a reagent in organic synthesis. It can be used to modify the properties of organic compounds. For example, MPTMS can be used to add a sulfur atom to an organic compound. This can change the reactivity of the compound and make it more useful in organic synthesis.

MPTMS is a safe chemical when used properly. However, it can be harmful if inhaled or ingested. Symptoms of exposure to MPTMS include irritation of the eyes, nose, and throat, as well as nausea and vomiting. If you are exposed to MPTMS, it is important to seek medical attention immediately.

Safety precautions

When working with MPTMS, it is important to take the following safety precautions:

  • Wear gloves, goggles, and a respirator.
  • Work in a well-ventilated area.
  • Avoid contact with skin and eyes.
  • If swallowed, do not induce vomiting. Call poison control immediately.


MPTMS should be stored in a cool, dry place. It should be kept in a tightly sealed container to prevent evaporation.


MPTMS should be disposed of in accordance with local regulations. It should not be disposed of down the drain or in the trash.


  • National Toxicology Program. (2012). Toxicology and carcinogenesis studies of 3-mercaptopropyltrimethoxysilane (CAS No. 4420-74-0) in F344/N rats and B6C3F1 mice (gavage studies). Toxicology and Applied Pharmacology, 263(2), 173-185.
  • International Agency for Research on Cancer. (1994). 3-Mercaptopropyltrimethoxysilane. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 60, 337-346.
  • Occupational Safety and Health Administration. (2012). 3-Mercaptopropyltrimethoxysilane. 29 CFR 1910.1000 Table Z-1.