(3-Mercaptopropyl)triethoxysilane CAS 14814-09-6: A Versatile Reagent for Thiol Functionalization

(3-Mercaptopropyl)triethoxysilane CAS 14814-09-6: A Versatile Reagent for Thiol Functionalization

(3-Mercaptopropyl)triethoxysilane CAS 14814-09-6 (MPTS) is a silane compound with the molecular formula C9H22O3SSi and the CAS number 14814-09-6. It is also known as 3-triethoxysilyl-1-propanethiol or γ-mercaptopropyltriethoxysilane. MPTS is a clear to straw-colored liquid with an unpleasant sulfide odor. It has a density of 0.987 g/mL at 20°C and a flash point of 88°C.


MPTS is a useful reagent for introducing thiol groups onto various materials, such as silica, alumina, starch, graphene, and polymers. Thiol groups are reactive and can form strong bonds with metals, such as gold, silver, copper, and mercury. This makes MPTS-functionalized materials suitable for applications in catalysis, biosensors, nanotechnology, and environmental remediation.


One of the advantages of MPTS is that it can react with both hydroxyl and amino groups on the surface of materials. This allows for a wide range of substrates to be modified with MPTS. Another advantage is that MPTS can form self-assembled monolayers (SAMs) on metal surfaces, which can improve the stability and functionality of the thiol groups.


MPTS can be applied to materials by various methods, such as dipping, spraying, spin coating, or vapor deposition. The reaction conditions depend on the type and concentration of MPTS, the nature and pretreatment of the substrate, the solvent, the temperature, and the reaction time. The degree of functionalization can be controlled by adjusting these parameters.


MPTS is commercially available from several suppliers, such as Sigma-Aldrich, Spectrum Chemical, and Pengrun New Materials. It is usually sold as a technical grade product with a purity of ≥80% (GC). MPTS should be stored in a cool and dry place, away from light, heat, and moisture. It should also be handled with care, as it is combustible and harmful to aquatic life.


MPTS is a versatile reagent for thiol functionalization of various materials. It can be used to create novel and functional materials for various applications in science and technology.

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